立命館大学 
増山研 分子栄養学研究室

研究業績

学術論文

Vitamin Status and Mineralized Tissue Development 
Kimie Nakagawa, Yumi Okubo, Ritsuko Masuyama
Current Oral Health Reports 5 89-95 2018

Phosphate-dependent luminal ATP metabolism regulates transcellular calcium transport in intestinal epithelial cells. 
Uekawa A, Yamanaka H, Lieben L, Kimira Y, Uehara M, Yamamoto Y, Kato S, Ito K, Carmeliet G, Masuyama R
FASEB journal 32(4) 1903-1915 2018

M1 and M2 Monocytes in Rheumatoid Arthritis: A Contribution of Imbalance of M1/M2 Monocytes to Osteoclastogenesis. 
Shoichi Fukui, Naoki Iwamoto, Ayuko Takatani, Takashi Igawa, Toshimasa Shimizu, Masataka Umeda, Ayako Nishino, Yoshiro Horai, Yasuko Hirai, Tomohiro Koga, Shin-Ya Kawashiri, Mami Tamai, Kunihiro Ichinose, Hideki Nakamura, Tomoki Origuchi, Ritsuko Masuyama, Kosuke Kosai, Katsunori Yanagihara, Atsushi Kawakami
Frontiers in immunology 8 1958 - 1958 2017

Calcification in dermal fibroblasts from a patient with GGCX syndrome accompanied by upregulation of osteogenic molecules. 
Okubo Y, Masuyama R, Iwanaga A, Koike Y, Kuwatsuka Y, Ogi T, Yamamoto Y, Endo Y, Tamura H, Utani A
PloS one 12(5) 0177375 2017

Methotrexate inhibits osteoclastogenesis by decreasing RANKL-induced calcium influx into osteoclast progenitors. 
Kanagawa H, Masuyama R, Morita M, Sato Y, Niki Y, Kobayashi T, Katsuyama E, Fujie A, Hao W, Tando T, Watanabe R, Miyamoto K, Morioka H, Matsumoto M, Toyama Y, Saya H, Miyamoto T
Journal of bone and mineral metabolism 34(5) 526-531 2016

Extra-intestinal calcium handling contributes to normal serum calcium levels when intestinal calcium absorption is suboptimal. 
Lieben L, Verlinden L, Masuyama R, Torrekens S, Moermans K, Schoonjans L, Carmeliet P, Carmeliet G
Bone 81 502-512 2015

Physiological functions of vitamin D: what we have learned from global and conditional VDR knockout mouse studies. 
Suda T, Masuyama R, Bouillon R, Carmeliet G
Current opinion in pharmacology 22 87-99 2015

Identification and characterization of vancomycin-resistant Enterococcus species frequently isolated from laboratory mice. 
Yamanaka H, Takagi T, Ohsawa M, Yamamoto N, Kubo N, Takemoto T, Sasano S, Masuyama R, Ohsawa K
Experimental animals 63(3) 297-304 2014

Vitamin D endocrine system and the intestine. 
Christakos S, Lieben L, Masuyama R, Carmeliet G
BoneKEy reports 3 496 2014

Role of local vitamin D signaling and cellular calcium transport system in bone homeostasis. 
Masuyama R
Journal of bone and mineral metabolism 32(1) 1-9 2014

Calcium/calmodulin-signaling supports TRPV4 activation in osteoclasts and regulates bone mass. 
Masuyama R, Mizuno A, Komori H, Kajiya H, Uekawa A, Kitaura H, Okabe K, Ohyama K, Komori T
Journal of bone and mineral research 27(8) 1708-1721 2012

Normocalcemia is maintained in mice under conditions of calcium malabsorption by vitamin D-induced inhibition of bone mineralization. 
Lieben L, Masuyama R, Torrekens S, Van Looveren R, Schrooten J, Baatsen P, Lafage-Proust MH, Dresselaers T, Feng JQ, Bonewald LF, Meyer MB, Pike JW, Bouillon R, Carmeliet G
The Journal of clinical investigation 122(5) 1803-1815 2012

Mutations in UVSSA cause UV-sensitive syndrome and impair RNA polymerase IIo processing in transcription-coupled nucleotide-excision repair. 
Nakazawa Y, Sasaki K, Mitsutake N, Matsuse M, Shimada M, Nardo T, Takahashi Y, Ohyama K, Ito K, Mishima H, Nomura M, Kinoshita A, Ono S, Takenaka K, Masuyama R, Kudo T, Slor H, Utani A, Tateishi S, Yamashita S, Stefanini M, Lehmann AR, Yoshiura K, Ogi T
Nature genetics 44(5) 586-592 2012

Toxicoproteomic analysis of a mouse model of nonsteroidal anti-inflammatory drug-induced gastric ulcers. 
Ohyama K, Shiokawa A, Ito K, Masuyama R, Ichibangase T, Kishikawa N, Imai K, Kuroda N
Biochemical and biophysical research communications 420(1) 210-215 2012

Pyruvate dehydrogenase kinase 4 induces bone loss at unloading by promoting osteoclastogenesis. 
Wang Y, Liu W, Masuyama R, Fukuyama R, Ito M, Zhang Q, Komori H, Murakami T, Moriishi T, Miyazaki T, Kitazawa R, Yoshida CA, Kawai Y, Izumi S, Komori T
Bone 50(1) 409-419 2012

Calcemic actions of vitamin D: effects on the intestine, kidney and bone. 
Lieben L, Carmeliet G, Masuyama R
Best practice & research. Clinical endocrinology & metabolism 25(4) 561-572 2011

IL-12- and IL-18-mediated, nitric oxide-induced apoptosis in TNF-α-mediated osteoclastogenesis of bone marrow cells. 
Kitaura H, Fujimura Y, Yoshimatsu M, Kohara H, Morita Y, Aonuma T, Fukumoto E, Masuyama R, Yoshida N, Takano-Yamamoto T
Calcified tissue international 89(1) 65-73 2011

IFN-γ directly inhibits TNF-α-induced osteoclastogenesis in vitro and in vivo and induces apoptosis mediated by Fas/Fas ligand interactions. 
Kohara H, Kitaura H, Fujimura Y, Yoshimatsu M, Morita Y, Eguchi T, Masuyama R, Yoshida N
Immunology letters 137(1) 53-61 2011

Overexpression of Bcl2 in osteoblasts inhibits osteoblast differentiation and induces osteocyte apoptosis. 
Moriishi T, Maruyama Z, Fukuyama R, Ito M, Miyazaki T, Kitaura H, Ohnishi H, Furuichi T, Kawai Y, Masuyama R, Komori H, Takada K, Kawaguchi H, Komori T
PloS one 6(11) 27487 2011

TRPV4-mediated calcium influx regulates terminal differentiation of osteoclasts. 
Masuyama R, Vriens J, Voets T, Karashima Y, Owsianik G, Vennekens R, Lieben L, Torrekens S, Moermans K, Vanden Bosch A, Bouillon R, Nilius B, Carmeliet G
Cell metabolism 8(3) 257-265 2008

Comparative activities of daidzein metabolites, equol and O-desmethylangolensin, on bone mineral density and lipid metabolism in ovariectomized mice and in osteoclast cell cultures. 
Ohtomo T, Uehara M, Peñalvo JL, Adlercreutz H, Katsumata S, Suzuki K, Takeda K, Masuyama R, Ishimi Y
European journal of nutrition 47(5) 273-279 2008

Vitamin D resistance. 
Bouillon R, Verstuyf A, Mathieu C, Van Cromphaut S, Masuyama R, Dehaes P, Carmeliet G
Best practice & research. Clinical endocrinology & metabolism 20(4) 627-645 2006

Vitamin D receptor in chondrocytes promotes osteoclastogenesis and regulates FGF23 production in osteoblasts. 
Masuyama R, Stockmans I, Torrekens S, Van Looveren R, Maes C, Carmeliet P, Bouillon R, Carmeliet G
The Journal of clinical investigation 116(12) 3150-3159 2006

Dietary fibers from mushroom sclerotia. 4. In vivo mineral absorption using ovariectomized rat model. 
Wong KH, Katsumata S, Masuyama R, Uehara M, Suzuki K, Cheung PC
Journal of agricultural and food chemistry 54(5) 1921-1927 2006

High-phosphorus diet stimulates receptor activator of nuclear factor-kappaB ligand mRNA expression by increasing parathyroid hormone secretion in rats. 
Katsumata S, Masuyama R, Uehara M, Suzuki K
The British journal of nutrition 94(5) 666-674 2005

Reduction in dietary calcium/phosphorus ratio reduces bone mass and strength in ovariectomized rats enhancing bone turnover. 
Koshihara M, Masuyama R, Uehara M, Suzuki K
Bioscience, biotechnology, and biochemistry 69(10) 1970-1973 2005

Decreased mRNA expression of the PTH/PTHrP receptor and type II sodium-dependent phosphate transporter in the kidney of rats fed a high phosphorus diet accompanied with a decrease in serum calcium concentration. 
Katsumata S, Masuyama R, Uehara M, Suzuki K
Bioscience, biotechnology, and biochemistry 68(12) 2484-2489 2004

Effects of simultaneous increases in dietary phosphorus and magnesium concentrations on nephrocalcinosis and kidney function in female rats. 
Matsuzaki H, Masuyama R, Uehara M, Nakamura K, Suzuki K
Magnesium research 17 14-19 2004

Effect of dietary calcium: Phosphorus ratio on bone mineralization and intestinal calcium absorption in ovariectomized rats. 
Koshihara M, Masuyama R, Uehara M, Suzuki K
BioFactors 22 39-42 2004

Effect of high phosphorus diet on phosphorus metabolism in parathyroidectomized rats. 
Katsumata S, Masuyama R, Koshihara M, Matsuzaki H, Uehara M, Suzuki K
BioFactors 22 33-37 2004

High phosphorus diet changes phosphorus metabolism regardless of PTH action in rats. 
Katsumata S, Masuyama R, Koshihara M, Matsuzaki H, Uehara M, Suzuki K
Bioscience, biotechnology, and biochemistry 68 243-246 2004

Dietary calcium and phosphorus ratio regulates bone mineralization and turnover in vitamin D receptor knockout mice by affecting intestinal calcium and phosphorus absorption. 
Masuyama R, Nakaya Y, Katsumata S, Kajita Y, Uehara M, Tanaka S, Sakai A, Kato S, Nakamura T, Suzuki K
Journal of bone and mineral research 18 1217-1226 2003

Hesperidin, a citrus flavonoid, inhibits bone loss and decreases serum and hepatic lipids in ovariectomized mice. 
Chiba H, Uehara M, Wu J, Wang X, Masuyama R, Suzuki K, Kanazawa K, Ishimi Y
The Journal of nutrition 133 1892-1897 2003

Dose-responsive alteration in hepatic lipid peroxidation and retinol metabolism with increasing dietary beta-carotene in iron deficient rats. 
Ikeda R, Uehara M, Takasaki M, Chiba H, Masuyama R, Furusho T, Suzuki K
International journal for vitamin and nutrition research 72 321-328 2002

Sex differences in kidney mineral concentrations and urinary albumin excretion in rats given high-phosphorus feed. 
Matsuzaki H, Katsumata S, Masuyama R, Uehara M, Nakamura K, Suzuki K
Bioscience, biotechnology, and biochemistry 66 1737-1739 2002

Changes in N-acetyl-beta-D-glucosaminidase activity in the urine and urinary albumin excretion in magnesium deficient rats. 
Matsuzaki H, Ohdachi J, Fuchigami M, Masuyama R, Uehara M, Nakamura K, Suzuki K
Bioscience, biotechnology, and biochemistry 66 192-194 2002

Greater effect of dietary potassium tripolyphosphate than of potassium dihydrogenphosphate on the nephrocalcinosis and proximal tubular function in female rats from the intake of a high-phosphorus diet. 
Matsuzaki H, Masuyama R, Uehara M, Nakamura K, Suzuki K
Bioscience, biotechnology, and biochemistry 65 928-934 2001

Dietary phosphorus restriction reverses the impaired bone mineralization in vitamin D receptor knockout mice. 
Masuyama R, Nakaya Y, Tanaka S, Tsurukami H, Nakamura T, Watanabe S, Yoshizawa T, Kato S, Suzuki K
Endocrinology 142 494-497 2001

High P diet induces acute secretion of parathyroidhormone without alteration of serum calcium levels in rats. 
Masuyama R, Uehara M, Suzuki K
Bioscience, biotechnology, and biochemistry 64 2316-2319 2000

Chronic phosphorus supplementation decreases the expression of renal PTH/PTHrP receptor mRNA in rats. 
Masuyama R, Kajita Y, Odachi J, Uehara M, Shigematsu T, Suzuki K, Goto S
American journal of nephrology 20(491-495) 2000

Dietary magnesium supplementation affects bone metabolism and dynamic strength of bone in ovariectomized rats. 
Toba Y, Kajita Y, Masuyama R, Takada Y, Suzuki K, Aoe S
The Journal of nutrition 130 216-220 2000

High phosphorus feeding decreases the expression of renal PTH/PTHRP-receptor mRNA in rats. 
Masuyama R, Suzuki K
BioFactors (Oxford, England) 12 53-58 2000

Comparison of various phosphate salts as the dietary phosphorus source on nephrocalcinosis and kidney function in rats. 
Matsuzaki H, Kikuchi T, Kajita Y, Masuyama R, Uehara M, Goto S, Suzuki K
Journal of nutritional science and vitaminology 45(5) 595-523 1999

Diminished kidney function and nephrocalcinosis in rats fed a magnesium-deficient diet. 
Kikuchi T, Matsuzaki H, Sato S, Kajita Y, Chiba H, Tsuchiya H, Masuyama R, Uehara M, Suzuki K, Goto S
Journal of nutritional science and vitaminology 44(4) 515-523 1998

Phosphorus reduces renal receptivity for parathyroid hormone in rats. 
Ritsuko Masuyama, Mariko Uehara, Kazuharu Suzuki, Shiro Goto
Journal of Bone and Mineral Metabolism 14 26-30 1996

お問い合わせ

立命館大学 
食マネジメント学部
増山研 分子栄養学研究室

〒525-8577

滋賀県 草津市 野路東 1-1-1
アクロスウィング606
TEL/FAX 077-599-3057
実験室内線 (6162)

<大学院生募集>
立命館大学大学院 食マネジメント研究科
博士前期課程・博士後期課程

<研究補助員募集>
業務内容:実験作業およびデータ整理の補助

お問い合わせフォームよりご連絡ください。

問い合わせフォームはこちら
PAGE TOP